Influence of omegaven on structural changes of inner organs at experimental widespread purulent peritonitis


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Abstract

In experiment on 40 rabbits-males of chinchilla breed by means of light microscopy structural changes of small intestine, liver and heart were studied at an experimental widespread purulent peritonitis. It is established that in 6 hours after initiation of peritonitis systemic structural and haemodynamic changes of the specified bodies which were characterized by the expressed dystrophic and necrotic processes, interstitial hypostasis, inflammatory neutrophilic infiltration, vessels’ hyperaemia, stasis in microvasculature and diapedesis hemorrhages were observed. Application in the postoperative period at an experimental widespread purulent peritonitis of the fatty emulsion, containing omega-3-fatty acids, «Omegaven» promotes restoration of structure of small intestine, liver and heart, decrease in expressiveness of an inflammation, interferes with development of dystrophic and necrotic changes. Positive system action of a preparation specifies in expediency of its application in complex treatment of a widespread purulent peritonitis.

About the authors

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: afansurg@rambler.ru
Doctor of Med. Science, Prof., Academician of RAMS, President of the Association of General Surgeons of the Russian Federation, Head of the Department of General Surgery of the First MoscowState Medical University named after I.M. Sechenov, Chairman of the Problem Commission "Infection in Surgery" of the Interdepartmental Scientific Council for Surgery of RAMS and the Ministry of Health and Social Development

I.M. Sechenov First Moscow State Medical University

Email: vkosinets@yandex.by
Candidate of Med. Science, Doctoral Candidate of the Department of General Surgery of the First Moscow State Medical University named after I.M. Sechenov

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