The Role of Some Immune System Parameters in Forecasting Development Acute Mesenteric Ischemia Experiment

Abstract


Relevance Acute mesenteric ischemia currently holds a leading position in terms of mortality in acute surgical diseases.
The purpose of the study The aim of our study was to investigate limfogrammy blood correlated with the morphological structure of the bowel wall at different stages of acute arterial mesenteric ischemia in the experiment.
Materials and methods The study was performed on 24 male albino rats weighing 0,2-0,22 kg. limfogrammy to examine correlation with the blood in the gut morphological changes in different stages of acute arterial mesenteric ischemia. The latter is achieved by ligation of the cranial mesenteric artery at the base of the root of the mesentery. All animals were divided into three groups on blood taken at animals immunogramm to ligation, and then after 2, 6, and 8 hours in each group, respectively.
Results and their discussion It was established that the first hours of the cranial mesenteric artery occlusion in the general circulation is progressively reduced the total number of lymphocytes, mainly due to the decrease in B cells and NK- cells. The largest decrease in the number of lymphocytes was observed in necrotic stage of the disease (p <0.05).
Conclusion Results of the study indicate that the progressive reduction in the number of lymphocytes central venous blood in animals confirmed for acute arterial mesenteric ischemia and may be a factor in the adverse outcome.

Chita State Medical Academy, 39A Gor'kogo Str., Chita, 672090, Russian federation

Author for correspondence.
Email: zoyaartamonova@mail.ru
Assistant of the Department of General Surgery, Chita State Medical Academy, Chita

Chita State Medical Academy, 39A Gor'kogo Str., Chita, 672090, Russian federation

Email: namokonovev@mail.ru
MD, Prof., Head of Department of General Surgery, Chita State Medical Academy, Chita

Chita State Medical Academy, 39A Gor'kogo Str., Chita, 672090, Russian federation

Email: tpp6915@mail.ru
Ph.D., Senior Research Fellow Institute "Ecology", Chita State Medical Academy, Chita

Chita State Medical Academy, 39A Gor'kogo Str., Chita, 672090, Russian federation

Email: mail@vestnik-surgery.com
 PhD, Head of the Department of Histology, Chita State Medical Academy, Chita

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