Development of Bioimpedance Analysis Algorithm of Tumors on an Experimental Model with Transplanted Rs-1 Tumor

Abstract


Relevance It is difficult to distinguish tumor and normal tissues during surgical treatment of malignant tumors. Bioimpidance analysis is a possible method of diagnostics of tumors and intact tissues. The purpose of the study To investigate biophysical characteristics of RS-1 tumor and surrounding tissues. Materials and methods An experimental investigation was performed on 10 Wistar rats with transplanted RS-1 tumor (signetring cell carcinoma). Invasive bioimpedancemetry was produced by a device “BIM-II” for measuring the electrical impedance of biological tissues (Patent of Russian Federation № 2366360). After bioimpedancemetry histological examination was performed. Results and their discussion Differences between impedance of tumor and intact tissue (p<0,05) were revealed. Histological examination confirmed that the transplanted tumor was the signet-ring cell carcinoma (RS-1). There were not found any malignant cells in tissues surrounding the tumor during histological examination. Conclusion An algorithm based on bioimpedance analysis for the verification of the tumor and intact tissue was developed

Moscow State University of Medicine and Dentistry, Moscow, Russian Federation;
Smolensk State Medical Academy, Smolensk, Russian Federation

Author for correspondence.
Email: author@vestnik-surgery.com
MD, PhD, Professor of Surgery, Chief, Department of Surgery and Laboratory of Minimally Invasive Surgery, A.I. Evdokimov Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry, Moscow, Russian Federation;
Smolensk State Medical Academy, Smolensk, Russian Federation

Email: author@vestnik-surgery.com
MD, PhD, Associate Professor, Department of Surgery and Laboratory of Minimally Invasive Surgery, A.I. Evdokimov Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry, Moscow, Russian Federation;
Smolensk State Medical Academy, Smolensk, Russian Federation

Email: author@vestnik-surgery.com
MD, PhD, Assistant Professor, Department of General Surgery, Smolensk State Medical Academy

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