Comparative Morphological Efficiency Different Methodics of Pleurodesis by Hydrogen Peroxide Solutions and Talc

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Relevance Currently, the choice of effective and safe means for chemical pleurodesis is an urgent problem in the surgical treatment of spontaneous pneumothorax.
Objective The purpose of our research was to compare the effectiveness of various methods of pleurodesis in the experiment based on the macro and microscopic study material.
Materials and methods We used laboratory rats of the WISTAR line, weighing 180 grams, 200 individuals in the experiment. They were divided into three experimental groups and a control group of 50 rats each. Spontaneous pneumothorax was simulated on one side of the thorax of rats. One of the chemical agents was used in three experimental groups for carrying out the pleurodesis. The animals were observed and sacrificed in groups on days 3, 5, 7, 10, 30 of the experiment. Next, macro and microscopic changes in the lungs and adjacent tissues were described and compared. Regression models were constructed for the change in the number of free cell populations in the lung tissue during the process of analyzing data.
Results and its discussion The use of a 6% solution of hydrogen peroxide causes the formation of persistent pleural adhesions with a shorter duration and severity of the inflammatory process in comparison to the analogues. Regression models of the dynamics of the free cellular composition of the pulmonary stroma were created with the aim of predicting the adhesion process.
Conclusions The findings suggest that 6% solution of hydrogen peroxide have the maximum efficiency as a chemical agent for pleurodesis.

About the authors

Mikhail Sergeevich Izyumov

N. N. Burdenko Voronezh State Medical University

Author for correspondence.

surgeon, Chair of Hospital Surgery

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036

Viktor Viktorovich Bulynin

N. N. Burdenko Voronezh State Medical University


MD, Chair of Hospital Surgery

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036

Andrew Mikhailovich Bobrovskikh

N. N. Burdenko Voronezh State Medical University


PhD, Department of Pathological Anatomy

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036


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Copyright (c) 2017 Izyumov M.S., Bulynin V.V., Bobrovskikh A.M.

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