Optimization of antibacterial therapy in erysipelatous inflammation


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Abstract

Case histories of 217 patients who were hospitalized and underweat treatment at the surgical department of city clinical hospital № 8 (Ufa) during the period from 2005 to 2010 were investigated. The control group included 103 patients who received therapy according to the standards of providing medical aid envisaged for this pathology as well as symptomatic treatment and therapy for concomitant pathology. Antibacterial therapy was given to all patients. The main group under study consisted of 114 patients who received antibacterial therapy in our modification (the first subgroup received concomitant systemic enzymatic therapy the second subgroup received therapy in combination with intramuscular injections of oxytocin, the third subgroup received prolonged antibacterial therapy on the surface of lymphatic vessel endothelium. The use of systemic enzymotherapy, namely flogenzyme in combination with antibiotics at the beginning of the therapy course resulted in more rapid improvement in patients general condition (patients of the main group), decrease of body temperature, reduction of intoxication and normalization of laboratory findings. Among 40 patients who received antibacterial therapy concomitantly with systematic enzymotherapy by intramuscular injection of oxytocin no recurrences were observed during the period of 3 years. Lymphotropic antibacterial therapy of erysipelatous inflammation in all patients resulted in the decrease of body temperature, reduction of skin hyperemia and swelling that were observed on 2d - 3d day after treatment whereas in patients of the control group these indices were reduced only on the 5-th – 6-th day. The duration of in hospital treatment decreased on average by 3, 8 days.

About the authors

Башкирский государственный медицинский университет

Author for correspondence.
Email: hasanovag@mail.ru
Хасанов Анвар Гиниятович – д.м.н., проф., зав. кафедрой хирургических болезней Башкирско- го государственного медицинского университета Russian Federation

Башкирский государственный медицинский университет

Email: danis.com@yandex.ru
Шайбаков Данис Габдинурович – к.м.н., доц. ка- федры хирургических болезней Башкирского госу- дарственного медицинского университета Russian Federation

Башкирский государственный медицинский университет

Email: Mail@Vestnik-surgery.com
Нигматзянов Салим Салихович – к.м.н., асс. кафе- дры хирургических болезней Башкирского госу- дарственного медицинского университета Russian Federation

Башкирский государственный медицинский университет

Email: Mail@Vestnik-surgery.com
Карамова Регина Фоатовна – аспирант кафедры хи- рургических болезней Башкирского государствен- ного медицинского университета. Russian Federation

References

  1. Bednova V.N., Borisenko K.K., Novolotskaia T.I. i dr. An-
  2. tibiotiki i khimioterapiia.[Antibiotics and chemotherapy] 1998; 8: 45-46.
  3. Bukharin O.V., Usviatsov B.Ia. Bakterionositel'stvo (me-
  4. diko-ekologicheskii aspekt).[Bakterionositelstvo (medico-ecological aspect)] Ekaterinburg: UrO RAN.
  5. ; 206.
  6. Bukharin O.V., Skorobogatykh Iu.I., Kurlaev P.P. Eks-
  7. perimental'noe obosnovanie effektivnosti sochetan-
  8. nogo primeneniia tsiprofloksatsina s oksitotsinom. [Experimental reasons for efficiency of the combined use of ciprofloxacin with oxytocin.]
  9. Zhurnal mikrobiologii epidemiologii i immunobio-
  10. logii. 2007; 5: 70-73.
  11. Buianov V.M., Alekseev A.A. Limfologiia endotoksikoza.[Limfologiya of endotoxicosis].
  12. M.:Meditsina. 1990; 272.
  13. Ermolov A.S., Vasina T.A. Endolimfaticheskaia anti-
  14. bakterial'naia terapiia gnoino-septicheskikh oslozhne-
  15. nii i zabolevanii v khirurgii.[Endolymphatic antibacterial therapy it is purulent - septic complications and diseases in surgery]. Problemy limfologii
  16. i kolichestvennoi patologii. M. 1996; 12-14.
  17. Efimenko N.A., Novozhilov A.A., Knorring G.Iu. Si-
  18. stemnaia enzimoterapiia v gnoinoi khirurgii.[System enzimoterapiya in purulent surgery]. M.: RMA-
  19. PO. 2004; 56.
  20. Leshchenko I.G., Galkin P.A. Gnoinaia khirurgicheskaia in-
  21. fektsiia.[Purulent surgical infection]. Samara: GP «Perspektiva». 2003; 326.
  22. Neverov V.A., Klimov A.V., Sternin Iu.I. Primenenie
  23. preparatov Vobenzim i Flogenzim v kompleksnom le-
  24. chenii povrezhdenii oporno-dvigatel'nogo apparata.[Use of medicines Vobenzim and Flogenzim in complex treatment of damages of the musculoskeletal device.].
  25. Informatsionnoe pis'mo. SPb. 2002; 8.
  26. Pal'tsev M.A. Tsitokiny i ikh rol' v mezhkletochnykh vza-
  27. imodeistviiakh.[Tsitokina and their role in intercellular interactions]. Arkh. Pat. 1996; 6: 3-7.
  28. Panchenkov R.T., Vyrenkov Iu.E., Iarema I.V., Shcherba-
  29. kova E.G. Endolimfaticheskaia antibiotikoterapiia. [Endolymphatic atibiotikoterapiya].
  30. M.:Meditsina. 1984; 239.
  31. Remezov A.P., Knorring G.Iu. Sistemnaia enzimoterapiia
  32. kak sposob potentsirovaniia effekta antibakterial'-
  33. nykh sredstv.[ System enzimoterapiya as way of potentiation of effect of antibacterial means]. Antibiotiki i khimioterapiia. 2003; 48:
  34. : 30-33.
  35. Skorobogatykh Iu.I. Eksperimental'noe obosnovanie
  36. sochetannogo primeneniia tsiprofloksatsina s oksito-
  37. tsinom dlia mestnogo lecheniia gnoinykh ran.[Experimental justification of the combined use of ciprofloxacin with oxytocin for a mestnogolecheniye of purulent wounds.]. Disserta-
  38. tsiia na soiskanie uchenoi stepeni kandidata meditsin-
  39. skikh nauk. Orenburg. 2011.
  40. Faiazov R.R., Efremova O.A., Chistostupov N.S., Mekhdi-
  41. ev D.I. Novye podkhody k kompleksnomu lecheniiu rozhi-
  42. stogo vospaleniia v khirurgicheskoi praktike.[New approaches to complex treatment of an erysipelatous inflammation in surgical practice.]. Meditsin-
  43. skii Vestnik Bashkortostana. 2009; 3: 50-51.
  44. Khasanov A.G., Nurtdinov M.A., Ibragimov R.K. Vozmozh-
  45. nosti sovershenstvovaniia khirurgicheskogo lecheniia ro-
  46. zhistogo vospaleniia.[Possibilities of improvement of surgical treatment of an erysipelatous inflammation.]. Meditsinskii Vestnik Bashkor-
  47. tostana. 2009; 3: 46.
  48. Khasanov A.G., Timerbulatov M.V., Shaibakov D.G., Nurt-
  49. dinov M.A., Karamova R.F., Bakirov S.Kh., Nigmatzianov
  50. S.S., Men'shikov A.M. Sposob lecheniia rozhistogo vos-
  51. paleniia.[Way of treatment of an erysipelatous inflammation.]. Patent na izobretenie № 2424006 ot 20 iiulia
  52. g.
  53. Khasanov A.G., Shaibakov D.G., Sufiiarov I.F., Ibragi-
  54. mov R.K. Sposob lecheniia rozhistogo vospaleniia izo-
  55. bretenie.[Way of treatment of an erysipelatous inflammation.]. Patent RF № 2317085 ot 20.02.08.
  56. Iarema I.V., Myl'nikov P.M. Endolimfaticheskoe vve-
  57. denie antibiotikov kak novyi metod glubokoi anti-
  58. septiki.[Endolymphatic introduction of antibiotics as new method of deep antiseptics.]. Aseptika i antiseptika. 1979; 1: 62-63.
  59. Huizinga WKJ et al. J Amtimicrob Chemother. 1995; 544.
  60. Schlueter P., Stauder C. Harnwegs infektionen –
  61. Behandlungmit hydrolytischen Enzymen. TW Urologie
  62. Nephrologie. 8: 1996; 276-279.

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