Сharacteristics of the Wound Process in Regional Applications Aquacomplexes Glitserosolvata Titanium and Oxytocin in Experiment


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Relevance Wound treatment is one of the most acute problems in surgery. The most prospective way of wound treatment appears to be instillation of gel medication of with different chemical components having passive adsorptive and active anti-septic properties. The purpose of the study Is to study titanium glycerosolvate aqua complex and oxytocin application in aseptic soft tissue wound treatment. Materials and methods The research was done on 144 white rats. Depending on the type of regional treatment (titanium glycerosolvate aqua complex application, oxytocin application, or their combination) there were distinguished a control and 3 experimental groups. Study of wound treatment process peculiarities was carried with macroscopic, planimetric, histological, statistical research methods. Results and their discussion The data obtained prove evident influence of titanium glycerosolvate aqua complex and oxytocin regional application on reparative processes in aseptic wound. At that level of positive impact rating is as follows: oxytocin injection (11%) < titanium glycerosolvate aqua complex instillation (14%) < combined application (32%). Conclusion Analyzing results of the current research segment we may conclude on a statistically reasonable basis that investigated methods of treatment have evident mechanisms of action representing evident activation of total reparative process and epithelial structure differentiation that close wound defect. In case of mono therapy oxytocin injection has moderate positive effect on wound process, titanium glycerosolvate aqua complex instillation – middle-level intensity effect. Combined application of abovementioned methods has maximal effect on reparative process of early activation.

About the authors

N.N.Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036,
Russian Federation

Author for correspondence.
Email: lesyamohova@mail.ru
- Assistant of the Department of General Surgery of the Voronezh State Medical Academy. Burdenko Russian Federation

N.N.Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036,
Russian Federation

Email: author@vestnik-surgery.com
MD, Prof., Corresponding member of RAE, Head. Department of General Surgery, Director of the Institute of surgical infection Voronezh State Medical Academy. Burdenko, honored inventor of the Russian Federation, Chairman of the Voronezh branch of the Russian Society of Surgeons. Russian Federation

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