Optimization of antibacterial therapy in erysipelatous inflammation


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Abstract

Case histories of 217 patients who were hospitalized and underweat treatment at the surgical department of city clinical hospital № 8 (Ufa) during the period from 2005 to 2010 were investigated. The control group included 103 patients who received therapy according to the standards of providing medical aid envisaged for this pathology as well as symptomatic treatment and therapy for concomitant pathology. Antibacterial therapy was given to all patients. The main group under study consisted of 114 patients who received antibacterial therapy in our modification (the first subgroup received concomitant systemic enzymatic therapy the second subgroup received therapy in combination with intramuscular injections of oxytocin, the third subgroup received prolonged antibacterial therapy on the surface of lymphatic vessel endothelium. The use of systemic enzymotherapy, namely flogenzyme in combination with antibiotics at the beginning of the therapy course resulted in more rapid improvement in patients general condition (patients of the main group), decrease of body temperature, reduction of intoxication and normalization of laboratory findings. Among 40 patients who received antibacterial therapy concomitantly with systematic enzymotherapy by intramuscular injection of oxytocin no recurrences were observed during the period of 3 years. Lymphotropic antibacterial therapy of erysipelatous inflammation in all patients resulted in the decrease of body temperature, reduction of skin hyperemia and swelling that were observed on 2d - 3d day after treatment whereas in patients of the control group these indices were reduced only on the 5-th – 6-th day. The duration of in hospital treatment decreased on average by 3, 8 days.

About the authors

Bashkir State Medical University

Author for correspondence.
Email: hasanovag@mail.ru
Doctor of Med. Science. Prof., Head of the Department of the Surgical Diseases of Bashkir State Medical University

Bashkir State Medical University

Email: danis.com@yandex.ru
Candidate of Med. Science, Assoc. Prof. of the Department of the Surgical Diseases of Bashkir State Medical University

Bashkir State Medical University

Email: admin@vestnik-surgery.com
Candidate of Med. Science, Assistant of the Department of the Surgical Diseases of Bashkir State Medical University

Bashkir State Medical University

Email: admin@vestnik-surgery.com
Postgraduate Student of the Department of the Surgical Diseases of Bashkir State Medical University

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