Optimization of antibacterial therapy in erysipelatous inflammation


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Abstract

Case histories of 217 patients who were hospitalized and underweat treatment at the surgical department of city clinical hospital № 8 (Ufa) during the period from 2005 to 2010 were investigated. The control group included 103 patients who received therapy according to the standards of providing medical aid envisaged for this pathology as well as symptomatic treatment and therapy for concomitant pathology. Antibacterial therapy was given to all patients. The main group under study consisted of 114 patients who received antibacterial therapy in our modification (the first subgroup received concomitant systemic enzymatic therapy the second subgroup received therapy in combination with intramuscular injections of oxytocin, the third subgroup received prolonged antibacterial therapy on the surface of lymphatic vessel endothelium. The use of systemic enzymotherapy, namely flogenzyme in combination with antibiotics at the beginning of the therapy course resulted in more rapid improvement in patients general condition (patients of the main group), decrease of body temperature, reduction of intoxication and normalization of laboratory findings. Among 40 patients who received antibacterial therapy concomitantly with systematic enzymotherapy by intramuscular injection of oxytocin no recurrences were observed during the period of 3 years. Lymphotropic antibacterial therapy of erysipelatous inflammation in all patients resulted in the decrease of body temperature, reduction of skin hyperemia and swelling that were observed on 2d - 3d day after treatment whereas in patients of the control group these indices were reduced only on the 5-th – 6-th day. The duration of in hospital treatment decreased on average by 3, 8 days.

About the authors

Bashkir State Medical University

Author for correspondence.
Email: hasanovag@mail.ru
Doctor of Med. Science. Prof., Head of the Department of the Surgical Diseases of Bashkir State Medical University

Bashkir State Medical University

Email: danis.com@yandex.ru
Candidate of Med. Science, Assoc. Prof. of the Department of the Surgical Diseases of Bashkir State Medical University

Bashkir State Medical University

Email: admin@vestnik-surgery.com
Candidate of Med. Science, Assistant of the Department of the Surgical Diseases of Bashkir State Medical University

Bashkir State Medical University

Email: admin@vestnik-surgery.com
Postgraduate Student of the Department of the Surgical Diseases of Bashkir State Medical University

References

  1. Bednova V.N., Borisenko K.K., Novolotskaia T.I. i dr. Antibiotiki i khimioterapiia.[Antibiotics and chemotherapy]. 1998; 8: 45-46.
  2. Bukharin O.V., Usviatsov B.Ia. Bakterionositel'stvo (mediko-ekologicheskii aspekt).[Bakterionositelstvo (Medico-ecological aspect).]. Ekaterinburg: UrO RAN. 1996; 206.
  3. Bukharin O.V., Skorobogatykh Iu.I., Kurlaev P.P. Eksperimental'noe obosnovanie effektivnosti sochetannogo primeneniia tsiprofloksatsina s oksitotsinom.[Experimental reasons for efficiency of the combined use of ciprofloxacin with oxytocin.]. Zhurnal mikrobiologii epidemiologii i immunobiologii. 2007; 5: 70-73.
  4. Buianov V.M., Alekseev A.A. Limfologiia endotoksikoza.[Limfologiya of endotoxicosis]. M.:Meditsina. 1990; 272.
  5. Ermolov A.S., Vasina T.A. Endolimfaticheskaia antibakterial'naia terapiia gnoino-septicheskikh oslozhnenii i zabolevanii v khirurgii.[Endolymphatic antibacterial therapy it is purulent - septic complications and diseases in surgery. ]. Problemy limfologii i kolichestvennoi patologii. M. 1996; 12-14.
  6. Efimenko N.A., Novozhilov A.A., Knorring G.Iu. Sistemnaia enzimoterapiia v gnoinoi khirurgii.[System enzimoterapiya in purulent surgery. ]. M.: RMAPO. 2004; 56.
  7. Leshchenko I.G., Galkin P.A. Gnoinaia khirurgicheskaia infektsiia.[Purulent surgical infection]. Samara: GP «Perspektiva». 2003; 326.
  8. Neverov V.A., Klimov A.V., Sternin Iu.I. Primenenie preparatov Vobenzim i Flogenzim v kompleksnom lechenii povrezhdenii oporno-dvigatel'nogo apparata.[Use of medicines Vobezin and Flogenzim in complex treatment of damages of the musculoskeletal device.]. Informatsionnoe pis'mo. SPb. 2002; 8.
  9. Pal'tsev M.A. Tsitokiny i ikh rol' v mezhkletochnykh vzaimodeistviiakh.[Tsitokina and their role in intercellular interaction.]. Arkh. Pat. 1996; 6: 3-7.
  10. Panchenkov R.T., Vyrenkov Iu.E., Iarema I.V., Shcherbakova E.G. Endolimfaticheskaia antibiotikoterapiia.[Endolymphatic antibiotic treatment]. M.:Meditsina. 1984; 239.
  11. Remezov A.P., Knorring G.Iu. Sistemnaia enzimoterapiia kak sposob potentsirovaniia effekta antibakterial'nykh sredstv.[System enzimoterapiya as way of potentiation of effect of antibacterial means.]. Antibiotiki i khimioterapiia. 2003; 48: 3: 30-33.
  12. Skorobogatykh Iu.I. Eksperimental'noe obosnovanie sochetannogo primeneniia tsiprofloksatsina s oksitotsinom dlia mestnogo lecheniia gnoinykh ran.[Experimental justification of the combined use of ciprofloxacin with oxytocin for local treatment of purulent wounds.]. Dissertatsiia na soiskanie uchenoi stepeni kandidata meditsinskikh nauk. Orenburg. 2011.
  13. Faiazov R.R., Efremova O.A., Chistostupov N.S., Mekhdiev D.I. Novye podkhody k kompleksnomu lecheniiu rozhistogo vospaleniia v khirurgicheskoi praktike.[New approaches to complex treatment of an erysipelatous inflammation in surgical practice.]. Meditsinskii Vestnik Bashkortostana. 2009; 3: 50-51.
  14. Khasanov A.G., Nurtdinov M.A., Ibragimov R.K. Vozmozhnosti sovershenstvovaniia khirurgicheskogo lecheniia rozhistogo vospaleniia.[Possibilities of improvement of surgical treatment of an erysipelatous inflammation. ] Meditsinskii Vestnik Bashkortostana. 2009; 3: 46.
  15. Khasanov A.G., Timerbulatov M.V., Shaibakov D.G., Nurtdinov M.A., Karamova R.F., Bakirov S.Kh., Nigmatzianov S.S., Men'shikov A.M. Sposob lecheniia rozhistogo vospaleniia.[Way of treatment of an erysipelatous inflammation]. Patent na izobretenie № 2424006 ot 20 iiulia 2011 g.
  16. Khasanov A.G., Shaibakov D.G., Sufiiarov I.F., Ibragimov R.K. Sposob lecheniia rozhistogo vospaleniia izobretenie.[Way of treatment of an erysipelatous inflammation]. Patent RF № 2317085 ot 20.02.08.
  17. Iarema I.V., Myl'nikov P.M. Endolimfaticheskoe vvedenie antibiotikov kak novyi metod glubokoi antiseptiki.[Endolymphatic introduction of antibiotics as new method of deep antiseptics.]. Aseptika i antiseptika. 1979; 1: 62-63.
  18. Huizinga WKJ et al. J Amtimicrob Chemother. 1995; 544.

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