Wound infection prevention and morphological aspects of aseptic wound healing


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Abstract

By means of morphological researches executed within an experimental framework it is identified that a considerable
increase in endothelial monolayer covering the wound surface is immunohistochemically observed after NO-management of
the wound. In turn, cryofractographic identification of small pits on splits of endotheliocytes indicates an increase in density
of plasmalemmal vesicules in capillary endothelium of dermal and muscule tissue of the wound surface. Activation of the
specified reactions promotes an intensification of neoangiogenesis as convincingly confirmed by a considerable increase in
length of microvasculature in 1 mm3 of forming granulations, verified at scanning electronic microscopy. At the same time,
the immunohistochemical research results indicate a considerable increase in proliferative activity of stab cells of epidermis
of vulnar surfaces. The set of the listed changes reflects brightly pathogenetic positivity of the influence of exogenetic nitrogen
monoxide on the course of wound process, mainly, on its reparative component.

About the authors

Ярославская государственная медицинская академия

Author for correspondence.
Email: author@vestnik-surgery.com
Ларичев Андрей Борисович – д.м.н., проф., зав. кафедрой общей хирургии Ярославской государ- ственной медицинской академии; e-mail: larichab@mail.ru

Российская медицинская академия последипломного образования

Email: author@vestnik-surgery.com
Шишло Владимир Константинович – к.м.н., до- цент, ст. науч. сотр. научного отдела оперативной хирургии и клинической лимфологии Российской медицинской академии последипломного образо- вания; e-mail: larich-ab@mail.ru

Ярославская государственная медицинская академия

Email: author@vestnik-surgery.com
Лисовский Александр Валерьевич – аспирант кафе- дры общей хирургии Ярославской государственной медицинской академии; e-mail: larich-ab@mail.ru

Ярославская государственная медицинская академия

Email: author@vestnik-surgery.com
Чистяков Андрей Леонидович – кандидат медицин- ских наук, врач-хирург Ярославского областного клинического онкологического диспансера; e-mail: larich-ab@mail.ru

Ярославская государственная медицинская академия

Email: author@vestnik-surgery.com
Васильев Андрей Андреевич – аспирант кафедры общей хирургии Ярославской государственной ме- дицинской академии; e-mail: larich-ab@mail.ru

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