On the Question of the Pathogenesis and Classification of Liver Failure


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Abstract

The liver failure is the actual problem of modern surgery. It is great scientific interest to study the features of liver failure in patients with obstruction of the biliary tract. Abnormal liver function in surgical practice are common, but are treated differently, as in parallel with the progression of cholestasis are always evolving phenomenon of liver failure. Aim of this study was to evaluate the biochemical and morphological criteria of liver failure in patients with obstructive jaundice. The analysis of the clinical data of 23 patients with obstructive jaundice benign and tumor genesis is presented. All patients underwent percutaneus transhepatic cholangiostomy. Patients were devided into 5 groups of comparison. The resulting differences in clinical biochemical indicators and liver biopsy allowed to develop its own classification of liver failure. The presented data demonstrate the primacy of bile ductal changes in patients with obstructive jaundice and can use it as a qualitive change criterion for assessing liver failure.

About the authors

I.P. Pavlov Riazan' State Medical University, 9 Vysokovol'tnaia Str., Riazan', 390026, Russian Federation

Author for correspondence.
Email: bsmp@mail.ryazan.ru
MD, Prof., Head of Hospital Surgery Department "Ryazan State Medical University. Acad. Pavlov ", member of Ed. board of the journal "Bulletin of Experimental and Clinical Surgery"

I.P. Pavlov Riazan' State Medical University, 9 Vysokovol'tnaia Str., Riazan', 390026, Russian Federation

Email: lorey1983@mail.ru
MD, assistant of Hospital Surgery Department "Ryazan State Medical University. Acad. Pavlov»

I.P. Pavlov Riazan' State Medical University, 9 Vysokovol'tnaia Str., Riazan', 390026, Russian Federation

Email: bsmp@mail.ryazan.ru
Surgeon of the 2nd surgical department GBU PO GK emergency hospital Ryazan

I.P. Pavlov Riazan' State Medical University, 9 Vysokovol'tnaia Str., Riazan', 390026, Russian Federation

Email: ozaitsev@rambler.ru
MD., assistant Prof. of the Hospital Surgery department "Ryazan State Medical University. Acad. Pavlov"

I.P. Pavlov Riazan' State Medical University, 9 Vysokovol'tnaia Str., Riazan', 390026, Russian Federation

Email: peskov_oleg_dmit@mail.ru
MD, assistant Prof. of the Hospital Surgery Department "Ryazan State Medical University. Acad. Pavlov"

I.P. Pavlov Riazan' State Medical University, 9 Vysokovol'tnaia Str., Riazan', 390026, Russian Federation

Email: levitin65@yandex.ru
the Head of pathology department GBU PO GK emergency hospital Ryazan

References

  1. Blumgart L.H., Foug Y. Ed Khirurgiya pecheni i zhelchnykh putey, 3-ye izd. Philadelphia: Saunders, [Surgery of the liver and biliary tract] 2000; 1639-1715.
  2. Bingener J., Schwesinger W.H Upravleniye obshchego zhelchnogo protoka kamney v sel'skoy mestnosti SSHA: rezul'taty oprosa.. Surgical Endoscopy [Management of common bile duct stones in the US countryside: Survey Results], 2006; 20: 577– 579.
  3. Child C.G., Turcotte J.G. Khirurgiya pecheni i portal'noy gipertenzii [Surgery of the liver and portal hypertension]. Edited by C.G.Child. Philadelphia: Saunders, 1964; 50-64..Dawson J.L. Brit. J. Surg., 1965; 52: 9: 663—665.
  4. Ghavami S., Hashemi M., Kadkhoda K. et al. Apoptosis in liver diseases detection and therapeutic applictions [Apoptoz pri vyiavlenii zabolevanii pecheni i terapevticheskikh primenenii]. Med. Sci. Monit., 2005; 11: 52: 3337–3345.
  5. Grintsalis K., Papapostolou I., Assimakopoulos S.F. et al. Vremya, svyazannyye s izmeneniyami superoksid radikal'nykh urovney v razlichnykh organakh zhelchnykh protokov ligiruyut stavok [Time associated with changing levels of superoxide radical in various organs of the bile ducts]. Free Radic. Res., 2009; 43: 9: 803–808.
  6. Kaplowitz N. Mekhanizmy povrezhdeniya kletok pecheni [Mechanisms of liver cell damage]. J. Hepatol., 2000; 32: 1: 39-47.
  7. Karadeniz G., Acikgoz S., Tekin I.O. et al. Oxidized lowdensityplipoprotein accumulation is associated with liver fibrosis in experimental cholestasis [Окисленные накопление липопротеина низкой плотности связано с фиброзом печени при экспериментальном холестазе]. Clinics, 2008; 63: 4: 2008.
  8. Morgan W.A., Kaler B., Bach P.H. Exp. Toxicol. Pathol., 1999; 51: 1: 35—39.
  9. Norman A. London, Nov. 1983. — Oxford, Washington, D.C. Proc. 1st Intern. Symp. Bile Acids Hepatobiliary and Gastrointest. Diseases [Желчные кислоты гепатобилиарной системы и желудочно-кишечного тракта.Заболевания]., 1984; 108—110.
  10. Rizzo C.C., de Castro S.J.O. Medicina (Bras.), 1997; 30: 2: 173—182.
  11. Tsai L.Y., Liu K.T., Lee T.Z. Fakticheskiye dannyye dlya uskoreniya generatsii gidroksil'nykh radikalov v eksperimental'noy zheltukhi krys
  12. [Evidence for accelerating regeneration of hydroxyl radicals
  13. experimental stomachs of rats]. Ann. Clin. Lab. Sci., 2001; 31: 4: 383–390.
  14. Younes R.N., Poggetti R.S., Fontes B. et al. Zheltukhi vyzyvayet ranneye ugneteniye dykhaniya mitokhondriy v gepatotsitakh [In the stomach, causing early respiratory depression mitochondria in hepatocytes]. Acta Chir. Bras., 2007; 22: 4.

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