Development of Bioimpedance Analysis Algorithm of Tumors on an Experimental Model with Transplanted Rs-1 Tumor


Cite item

Full Text

Abstract

Relevance It is difficult to distinguish tumor and normal tissues during surgical treatment of malignant tumors. Bioimpidance analysis is a possible method of diagnostics of tumors and intact tissues. The purpose of the study To investigate biophysical characteristics of RS-1 tumor and surrounding tissues. Materials and methods An experimental investigation was performed on 10 Wistar rats with transplanted RS-1 tumor (signetring cell carcinoma). Invasive bioimpedancemetry was produced by a device “BIM-II” for measuring the electrical impedance of biological tissues (Patent of Russian Federation № 2366360). After bioimpedancemetry histological examination was performed. Results and their discussion Differences between impedance of tumor and intact tissue (p<0,05) were revealed. Histological examination confirmed that the transplanted tumor was the signet-ring cell carcinoma (RS-1). There were not found any malignant cells in tissues surrounding the tumor during histological examination. Conclusion An algorithm based on bioimpedance analysis for the verification of the tumor and intact tissue was developed

About the authors

Moscow State University of Medicine and Dentistry, Moscow, Russian Federation;
Smolensk State Medical Academy, Smolensk, Russian Federation

Author for correspondence.
Email: author@vestnik-surgery.com
MD, PhD, Professor of Surgery, Chief, Department of Surgery and Laboratory of Minimally Invasive Surgery, A.I. Evdokimov Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry, Moscow, Russian Federation;
Smolensk State Medical Academy, Smolensk, Russian Federation

Email: author@vestnik-surgery.com
MD, PhD, Associate Professor, Department of Surgery and Laboratory of Minimally Invasive Surgery, A.I. Evdokimov Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry, Moscow, Russian Federation;
Smolensk State Medical Academy, Smolensk, Russian Federation

Email: author@vestnik-surgery.com
MD, PhD, Assistant Professor, Department of General Surgery, Smolensk State Medical Academy

References

  1. Akoev I.G. Biofizika poznaet rak [Biophysics knows
  2. cancer]. Moscow, Nauka Publ., 1988. 160 p. - (In Russian)
  3. Vasil'ev A.Iu., Duditskaia T.K., Vikulova Iu.V. Sravnitel'naya stepen' analiza vozmozhnostej mnogosrezovoj komp'yuternoj tomografii
  4. i magnitno-rezonansnoj tomografii v diagnostike opuholej
  5. polosti rta i rotoglotki [Comparative
  6. analysis of possibilities of multislice computed tomography
  7. and magnetic resonance imaging in the diagnosis of tumors
  8. of the oral cavity and oropharynx]. Radiologiia – praktika,
  9. ; 1: 4-10. - (In Russian)
  10. Vasil'ev S.A., Sandrikov V.A., Zuev A.A. Intraoperacionnaya sonografiya v hirurgii opuholej golovnogo mozga [Intraoperative
  11. sonography in surgery of brain tumors]. Neirokhirurgiia,
  12. ; 1: 36-43. - (In Russian)
  13. Godzhello E.A., Bulganina N.A., Khrustaleva M.V.
  14. Ehndosonografiya - sovremennyj metod diagnostiki
  15. podslizistyh struktur zheludochno-kishechnogo trakta [Endosonography - a modern method of diagnosis of
  16. submucosal structures of the gastrointestinal tract].
  17. Endoskopiia, 2012; 2: 3-11. - (In Russian)
  18. Demidov L.V., Martynova E.V., Perikhanian F.K.
  19. Vybor optimal'nyh predelov rezekcii dlya pervichnoj
  20. melanomy kozhi tulovishcha i konechnostej [The
  21. choice of the optimal limits of resection for the primary
  22. skin melanoma of trunk and extremities]. Vestnik RONTs im.
  23. N.N. Blokhina RAMN, 2003; 14: 2-1: 82-86. - (In Russian)
  24. Ivakhno K.Iu., Karnaukh P.A. Ispol'zovanie intraoperacionnogo
  25. ul'trazvuka dlya sohraneniya terapii raka pochki [The use of intraoperative
  26. ultrasound for conserving therapy of renal cancer].
  27. Meditsinskii vestnik Bashkortostana, 2011; 6: 2: 253-255. -
  28. (In Russian)
  29. Kiselev A.M., Esin I.V., Shikunova I.A. Kombinirovannaya nejronavigaciya v hirurgii zlokachestvennyh opuholej golovnogo mozga [Combined
  30. neuronavigation in surgery of malignant brain tumors].
  31. Al'manakh klinicheskoi meditsiny, 2011; 25: 58-63. - (In
  32. Russian)
  33. Likhvantseva V.G., Kogoniia L.M., Kharlap S.I. Sposob
  34. opredeleniia ob"ema rezektsii tkanei pri melanome kozhi
  35. [The method for determining the amount of tissue resected
  36. skin melanoma]. Patent RF, no. 2006125196/14, 2008. - (In
  37. Russian)
  38. Nevol'skikh A.A., Berdov B.A., Neborak Iu.T., Silant'eva
  39. N.K., Lantsov D.S. Bokovye kraya, kak rezekciya
  40. prognosticheskogo faktora dlya raka pryamoj kishki [ The lateral resection margin as a
  41. prognostic factor for rectal cancer]. Sibirskii onkologicheskii
  42. zhurnal, 2010; 5: 41: 5-10. - (In Russian)
  43. Petrova E.A., Berezovskaia T.P., Kariakin O.B. Lokalizovannyj rak predstatel'noj zhelezy: vozmozhnosti magnitnogo rezonansa
  44. formirovaniya izobrazheniya s pomoshch'yu gibkoj katushki matricy dlya opredeleniya minimal'nogo
  45. ehkstrakapsulyarnogo rasprostraneniya opuholi [Localized
  46. prostate cancer: possibilities of magnetic resonance
  47. imaging with a flexible matrix coil to identify the minimum
  48. of extracapsular tumor spread]. Onkourologiia, 2012; 4: 53-
  49. - (In Russian)
  50. Chissov V.I., Davydov M.I. Onkologiia: natsional'noe
  51. rukovodstvo [Oncology: the national manual]. Moscow,
  52. GEOTAR-Media Publ., 2013. 1072 p. - (In Russian)
  53. Shakhova N.M., Artifeksova A.A., Gelikonov N.D. Opticheskaya tomografiya v diagnostike raka [The
  54. optical imaging in the diagnosis of cancer]. Materialy
  55. Rossiiskogo onkologicheskogo kongressa [Proc. 13th
  56. Russian Cancer Congr.] Moscow, 2009, 390-391. -(In
  57. Russian). - (In Russian)
  58. Tsujimoto H., Ichikura T., Aiko S. i drugie. Multidetectorcomputed Znacheniya zatuhaniya tomografiya mezhdu ehtimi
  59. opuholi i stenki aorty v otvet na indukcionnuyu terapiyu
  60. dlya raka pishchevoda i ego prognosticheskuyu cennost' aortal'nogo
  61. vtorzhenie [Multidetectorcomputed
  62. tomography attenuation values between the
  63. tumor and aortic wall in response to induction therapy
  64. for esophageal cancer and its predictive value for aortic
  65. invasion]. Experimental and therapeutic medicine, 2012; 3:
  66. : 243-248.
  67. Vasile T.A., Feier D., Socaciu M. i drugie . Kontrast usilivaetsya
  68. UZI i komp'yuternaya tomografiya diagnostika tverdogo tela
  69. i smeshannye opuholi podzheludochnoj zhelezy - analiz vmeshivayushchihsya [Contrast enhanced
  70. ultrasound and computer tomography diagnosis of solid
  71. and mixed pancreatic tumors – analysis of confounders].
  72. Journal of Gastrointestinal and Liver Diseases, 2012; 21:
  73. : 285-292.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 ., ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies