Some Features of the Micrometastasis Arrangement in Ileal Lymph Nodes at the Cancer of Cervix Uteri

Abstract



The purpose of the study To study structure features of the lymph nodes removed from patients at a cer-vival cancer without metastasises.
Materials and methods The ileal lymph nodes without metastasises removed from patients at cervival can-cer in the time of a Wertheim hysterectomy or a radical trachelectomy were studied by method of a light microscopy.
Results and their discussion Small oval or elliptic micrometastasises of a high-differentiated adenocarcinoma up to 105 μm2 in 2 ileal lymph nodes from one patient from 56 surveyed were found. Tumoral struc-tures were present only in 3-4 serial organ cuts made through 50 μm in a row, and metastasises were never located in the plane of the maximal area of a lymph nodes which are usually studied by pathomorphologists during establishment or specification of the clinical diagnosis. These metastasis-es were located in the surface departments of a cortical plateau, practically on border with a subcap-sular sine or a nodular capsule. In both organs with the found micrometastasises the phenomenon of a paracortical and follicular hyperplasia were noted. That is characteristic for nodes without metasta-sises, but not for organs at early stages of development of metastasises, thus on indirect signs it is impossible to judge existence or absence of small tumoral structures in lymph nodes. 
Conclusion For detection of micrometastasises in lymph nodes it is necessary from all organ to make serial cuts with an interval no more than 100 microns. Besides, the lymph nodes with mi-crometastasises of a malignant tumor have a paracortical and follicular hyperplasia, the reference for nodes without metastasises that can testify to antigenic stimulation of these organs, activation of their protective functions directed against as well as the tumor and its metastasises.

Author for correspondence.
mail@vestnik-surgery.com
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation

MD, PhD, doctoral candidate of department of oncology of Novosibirsk state medical university 

mail@vestnik-surgery.com
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation

MD, PhD, DrSc(Med), professor, professor of department of oncology of Novosibirsk state medical university 

mail@vestnik-surgery.com
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation

graduate student of department of oncology of Novosibirsk state medical university 

mail@vestnik-surgery.com
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation

graduate student of department of oncology of Novosibirsk state medical university

imai@mail.ru
Institute of Chemical Biology and Fundamental Medicine, 8 Akademika Lavrent'eva Ave., Novosibirsk, 630090, Russian Federation

MD, PhD, DrSc(Med), professor, leading researcher of laboratory of a stem 
cell, Institute of chemical biology and fundamental medicine of the Siberian Branch of the Russian Academy of Science, Center of new medical technologies,

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