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Some Features of the Micrometastasis Arrangement in Ileal Lymph Nodes at the Cancer of Cervix Uteri
- Authors: 1, 1, 1, 1, 2
-
Affiliations:
- Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation
- Institute of Chemical Biology and Fundamental Medicine, 8 Akademika Lavrent'eva Ave., Novosibirsk, 630090, Russian Federation
- Issue: Vol 8, No 3 (2015)
- Pages: 291-295
- Section: Original articles
- URL: https://vestnik-surgery.com/journal/article/view/45
- DOI: https://doi.org/10.18499/2070-478X-2015-8-3-291-295
- ID: 45
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Abstract
The purpose of the study To study structure features of the lymph nodes removed from patients at a cer-vival cancer without metastasises. Materials and methods The ileal lymph nodes without metastasises removed from patients at cervival can-cer in the time of a Wertheim hysterectomy or a radical trachelectomy were studied by method of a light microscopy. Results and their discussion Small oval or elliptic micrometastasises of a high-differentiated adenocarcinoma up to 105 μm2 in 2 ileal lymph nodes from one patient from 56 surveyed were found. Tumoral struc-tures were present only in 3-4 serial organ cuts made through 50 μm in a row, and metastasises were never located in the plane of the maximal area of a lymph nodes which are usually studied by pathomorphologists during establishment or specification of the clinical diagnosis. These metastasis-es were located in the surface departments of a cortical plateau, practically on border with a subcap-sular sine or a nodular capsule. In both organs with the found micrometastasises the phenomenon of a paracortical and follicular hyperplasia were noted. That is characteristic for nodes without metasta-sises, but not for organs at early stages of development of metastasises, thus on indirect signs it is impossible to judge existence or absence of small tumoral structures in lymph nodes. Conclusion For detection of micrometastasises in lymph nodes it is necessary from all organ to make serial cuts with an interval no more than 100 microns. Besides, the lymph nodes with mi-crometastasises of a malignant tumor have a paracortical and follicular hyperplasia, the reference for nodes without metastasises that can testify to antigenic stimulation of these organs, activation of their protective functions directed against as well as the tumor and its metastasises. |
About the authors
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation
Author for correspondence.
Email: mail@vestnik-surgery.com
MD, PhD, doctoral candidate of department of oncology of Novosibirsk state medical university
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation
Email: mail@vestnik-surgery.com
MD, PhD, DrSc(Med), professor, professor of department of oncology of Novosibirsk state medical university
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation
Email: mail@vestnik-surgery.com
graduate student of department of oncology of Novosibirsk state medical university
Novosibirsk State Medical University, 52 Krasnyi Ave., Novosibirsk, 630091, Russina Federation
Email: mail@vestnik-surgery.com
graduate student of department of oncology of Novosibirsk state medical university
Institute of Chemical Biology and Fundamental Medicine, 8 Akademika Lavrent'eva Ave., Novosibirsk,
630090, Russian Federation
Email: imai@mail.ru
MD, PhD, DrSc(Med), professor, leading researcher of laboratory of a stem
cell, Institute of chemical biology and fundamental medicine of the Siberian Branch of the Russian Academy of Science, Center of new medical technologies,
References
- Anichkov N.M., Borisov A.V., Gabuniya U.A. Limfaticheskie puti i metastazirovanie raka. [Lymph way and metastasis of cancer.] Tbilisi: 1989; 128.
- Kolotova N.M., Majborodin I.V., Fursov S.A., Lushnikova E.L., Zarubenkov O.A., Majborodina V.I. Morfologiya pararektal'nyh limfaticheskih uzlov pri rake pryamoj kishki posle provedeniya neoad"yuvantnoj terapii. [Morphology adrectal lymph nodes in rectal cancer after neoadjuvant therapy.] Byulleten' ehksperimental'noj biologii i mediciny 2010; 149: 2: 213-218.
- Kravchenko S.V., Mikul'skaya S.K. Strukturnye izmeneniya v regionarnyh podchelyustnyh limfaticheskih uzlah pri zlokachestvennyh opuholyah chelyustno-licevoj oblasti. [Structural changes in the regional submandibular lymph nodes in malignant tumors of the maxillofacial region.] Stomatologiya 1983; 62: 4: 51-53.
- Cyplakov D.EH., Petrov S.V. Rak i regionarnye limfaticheskie uzly (immunogistohimicheskoe i ul'trastrukturnoe issledovanie). [Cancer and the regional lymph nodes (immunohistochemical and ultrastructural study)] Arhiv patologii 1997; 59: 1: 12–19.
- Cyplakov D.EH., Petrov S.V. Giperplasticheskaya follikulyarnaya reakciya regionarnyh limfaticheskih uzlov pri rake (immunogistohimiya, ul'trastruktura, prognosticheskoe znachenie). Arhiv patologii 1997; 4: 55–60.
- SHurkus V.EH., SHurkus E.A., Roman L.D. Ul'trazvukovaya diagnostika porazhenij limfaticheskih uzlov yaremnopodmyshechnogo limfokollektora s uchyotom ego geneza. Voprosy onkologii 1997; 43: 2: 224-227.
- Chen Y1, Zhang L, Tian J, Ren X, Hao Q. Combining the negative lymph nodes count with the ratio of positive and removed lymph nodes can better predict the postoperative survival in cervical cancer patients. Cancer Cell Int. 2013; 13: 1: 6.
- Morgagni P., Saragoni L., Folli S., Gaudio M., Scarpi E., Bazzocchi F., Marra G.A., Vio A. Lymph node micrometastases in patients with early gastric cancer: experience with 139 patients. Ann. Surg. Oncol. 2001; 8: 2: 170-174.
- Tsyplakov D.E., Petrov S.V., Kulagin R.N. Lymph node reaction to cancer. (Immunohistochemical and ultrastructural
- study). Pathol. Oncol. Res. 1997. 3: 2: 121-125.
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