Remote preconditioning influence on ischemic tissues survival potential


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Abstract

The investigation of remote preconditioning influence on isolated skin pedicle flap was taken. Also the role of К+ATP-channels was detected in the realization of positive remote preconditioning effect. Application of remote preconditioning allowed to half again as raise the survival potential of skin flap in comparison with control group. Preconditioning positive effect cancellation in introducing of К+ATP-channels blocker glibenclamid to animals witness that ATP-dependent К+-channels are important and necessary part in the realization of preconditioning positive effect.

About the authors

Kursk state medical University

Author for correspondence.
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
doctor of medical Sciences, Professor, head of the pharmacology Department of the Kursk state medical University, academician of RANS Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
doctor of medical Sciences, Professor, head of chair of surgical diseases of FPE, the rector of the Kursk state medical University, corresponding member of RANS, academician of MANEB, AMT, honored doctor of the Russian Federation Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
PhD, doctoral candidate of the Department of clinical pharmacology of Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
the candidate of medical Sciences, senior researcher of the Institute of Environmental medicine of Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
candidate of pharmacological Sciences, graduate school of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation

Kursk state medical University

Email: author@vestnik-surgery.com
the candidate of medical Sciences, assistant of the surgical diseases chair №2 of Kursk state medical University Russian Federation

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