Remote preconditioning influence on ischemic tissues survival potential
- Authors: 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
-
Affiliations:
- Kursk state medical University
- Issue: Vol 3, No 3 (2010)
- Pages: 214-217
- Section: Original articles
- URL: https://vestnik-surgery.com/journal/article/view/530
- DOI: https://doi.org/10.18499/2070-478X-2010-3-3-214-217
- ID: 530
Cite item
Full Text
Abstract
The investigation of remote preconditioning influence on isolated skin pedicle flap was taken. Also the role of К+ATP-channels was detected in the realization of positive remote preconditioning effect. Application of remote preconditioning allowed to half again as raise the survival potential of skin flap in comparison with control group. Preconditioning positive effect cancellation in introducing of К+ATP-channels blocker glibenclamid to animals witness that ATP-dependent К+-channels are important and necessary part in the realization of preconditioning positive effect.
Keywords
About the authors
Kursk state medical University
Author for correspondence.
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
doctor of medical Sciences, Professor, head of the pharmacology Department of the Kursk state medical University, academician of RANS Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
doctor of medical Sciences, Professor, head of chair of surgical diseases of FPE, the rector of the Kursk state medical University, corresponding member of RANS, academician of MANEB, AMT, honored doctor of the Russian Federation Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
PhD, doctoral candidate of the Department of clinical pharmacology of Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
the candidate of medical Sciences, senior researcher of the Institute of Environmental medicine of Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
candidate of pharmacological Sciences, graduate school of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
postgraduate student of the Department of pharmacology, Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
the candidate of medical Sciences, assistant of the surgical diseases chair №2 of Kursk state medical University Russian Federation
References
- Avtandilov G. G.[ Fundamentals of pathoanatomical practice.] M.: 1994, cum laude; 512.
- Artyushkova E. B.,. D Pashkov[.In, the knotty B. S. pharmacological correction of chronic limb ischemia in experiment. Kuban scientific medical Bulletin] 2007; 1-2: 19-22.
- Artyushkova E. B., D Pashkov.In., M Pokrovsky.[In. The possibilities of pharmacological correction of chronic limb ischemia in experiment. Experimental. and klinich. pharmacology ] 2008; 71: 3: 23-25.
- Artyushkova E. B., D Pashkov.In., Butchers, A. D. [the combination Possibilities of pharmacological and surgical correction of chronic limb ischemia in experiment. ROS. med.-biologist.] Vestn. them. Acad. I. P. Pavlov 2008; 1: 8-13.
- Samoilenkov N. With., Gurchenko I. L., Gavrilova S. A.[ Protective effect of hypoxic preconditioning in focal cerebral ischemia in rats. Proceedings of 4th Russian conference with international participation "Hypoxia: mechanisms, adaptation, correction"]. Moscow, 2005; 99-100.
- D Pashkov.In., M Pokrovsky.In., Kolesnik I. M.[ Assessment neoangiogenesis effect of L-arginine and its combination with plasmids of the gene for the growth factor of vascular endothelium in experimental Ishe is MII limbs. Kuban scientific medical Bulletin] 2009; 5: 102-106.
- L Torokina.In., Kolesnik, I. M., M. Pokrovsky. [Pharmacological correction of L-name induced deficiency of nitric oxide with recombinant erythropoietin. Kuban scientific medical journal ]2009; 9: 66-69.
- M Pokrovsky.In., T Intercession.G., In Kochkarov.And., Artyushkova E. B. [Endotheliopathy effects of L-arginine in the simulation of deficiency of nitric oxide Experimental and clinical pharmacology] 2008; 71: 2: 29-31.
- Hi J. M. [preconditioning and brain ischemic tolerance.] NAT Revs Neurosci. 2006; 7: 437-48.
- Samoilenkova N., Gurchenko I., Gavrilova, S., Lovat M., ionov V., Koshelev V. [protective effect of hypoxic and ischemic preconditionig in rats with focal cerebral ischemia. The FENS forum 2006.] Vienna, Austria, 2006; 3: A237.33.
- Stenzel-Poore, M. P., Stevens, S. L., king, S. J., Simon R. P. [Preconditioning preprogrammed response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke]. 2007; 38: 680-85.
- Dave K. R., de Fazio A. R., Raval A. P. [ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C-Epsilon. In J Neurosci.] 2008; 28: 4172-82.
- Miyawaki, T. Mashiko, T. D. [Ofengeim ischemic preconditioning blocks bad translocation, bcl-XL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc National Acad Sciences]
- USA. 2008; 105: 4892-97.