Participation of mutant genes in the pathogenesis of the idiopathic pancreatitis


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Abstract

The analysis of distribution of polymorphic variants of the genes of the cationic tripsinogen (PRSS1), inhibitor of tripsin
(SPINK1), regulator of the cystic fi brosis (CFTR) and genes of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1)
is carried out. This research was held according to the group of people, who have the disease of idiopathic pancreatitis (32
people). This group of people was compared with the donors (69 people). The gene mutation exists under the condition of the
appearing of the acute idiopathic pancreatitis. In Krasnoyarsk 31,25% patients, who have the acute pancreatitis and 9,4%
of patients with pancreatonecrosis have polymorphic variants of the gene GSTM1. The destructive form of the pancreatitis
is diagnosed for 28,1% of patients. Patients with idiopathic pancreatitis have the risk of development of the heavy form of
the disease in 33,3% of cases is caused by the isolated mutations of a gene inhibitor of tripsin. The mutations of the gene
of cation tripsinogen in a combination with the polymorphic variants of genes SPINK1, GSTM1, CFTR are lethal genetic
determinants defi ning an adverse current of the destructive process.

About the authors

Красноярский государственный медицинский университет им. профессора В.Ф.Войно-Ясенецкого

Author for correspondence.
Email: olga-pervova@mail.ru
д.м.н., профессор, за-
служенный деятель науки Российской Федерации,
заведующий кафедрой общей хирургии Краснояр-
ского государственного медицинского университе-
та им. профессора В.Ф.Войно-Ясенецкого

Красноярский государственный медицинский университет им. профессора В.Ф.Войно-Ясенецкого

Email: olga-pervova@mail.ru
д.м.н., профессор
кафедры общей хирургии Красноярского государ-
ственного медицинского университета им. профес-
сора В.Ф.Войно-Ясенецкого

Красноярский государственный медицинский университет им. профессора В.Ф.Войно-Ясенецкого

Email: olgapervova@mail.ru
д.м.н., про-
фессор, заведующий кафедрой хирургических бо-
лезней №1 с курсом сердечно-сосудистой хирур-
гии им. профессора А.М.Дыхно Красноярского
государственного медицинского университета им.
профессора В.Ф.Войно-Ясенецкого

Сибирский федеральный университет, г. Красноярск

Email: olga-pervova@mail.ru
к.б.н., доцент ка-
федры биохимии и физиологии животных тканей
Сибирского Федерального университета

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