The Ways to Study the Effectiveness of Various Schemes of the Antibiotic Prophylaxis of Postoperative Septic Complications, and the State of the Lymphatic System Drainage in the Experimental Postoperative Period


The purpose of the study Another option, proposed by the author, is a parallel combination of antibiotic prophylaxis and varying lymph stimulation. Materials and methods The study was conducted on 36 Wistar male rats. The effectiveness of antibiotic prevention in the conditions of new model of infectious complications in surgical area was studied in groups of 6 animals. Results and their discussion It is experimentally proved that for a given simulation of postoperative complications ABP is really effective, i.e. the number of operations undergone by animals increases. Means, this model takes place on existence and can be used to study various methods of ABP. The condition of a lymphatic drainageis oppressed during the development of pyoinflammatory complications in regional and distal lymph areas concerning a surgery zone. Conclusion Antibiotic dose used in the ABP does not affect the frequency of development of SSIs (p> 0,05), but severity of other complications depends on it (peritonitis, death) p≤0,05. Combining it with lymphostimulation using minimal doses improving its efficiency p ≤ 0,05. The isolated lymphostimulation in the experiment is prevention of development of SSIs

Perm State Pharmaceutical Academy, 2 Polevaia Str., Perm, 614990, Russian Federation

Author for correspondence.

Russian Federation Ph.D., Perm State Pharmaceutical Academy

  1. In Gorchakov.N. Morfologicheskie metody issledovaniya sosudistogo rusla. Sib. otd-nie RAMN, Institut klinicheskoj. i ehksperimental'nye. limfologii, 438, SO RAMN, Novosibirsk, [Morphological studies of the vascular bed. Sib. otd-nie RAMS, Institute of clinical. and experimental. lymphology, 438, SB RAMS, Novosibirsk,] 1997; 20-23.
  2. In Gostishchev.To. Puti i vozmozhnosti profilaktiki infekcionnyh oslozhnenij v hirurgii. Racional'nye podhody k profilaktike infekcionnyh oslozhnenij v hirurgii. [Ways and possibilities of prevention of infectious complications in surgery. Rational approaches to the prevention of infectious complications in surgery.] Moscow: Universum Pablishing, 1997; 2-11.
  3. Panchenkov R. T., Yarema I. V., Selmanovic N. N. Limfostimulyaciya [Lymphostimulation.] M., 1986; 242.
  4. P Popov.In., B Syropyatov.I. Vliyanie limfostimulyacii na limfaticheskij drenazh zadnej konechnosti krysy na fone Central'nogo limfostaza. Patologicheskaya fiziologiya i ehksperimental'naya terapiya. [The influence of lymphostimulation on the lymphatic drainage of the hind limb of rats on the background of the Central lymphostasis. Pathological physiology and experimental therapy.] 2008; 1: 12-14.
  5. P Popov.In., B Syropyatov.I., Odegova T. F. Sostoyanie limfaticheskogo drenazha zadnej konechnosti krys pri raznyh skhemah vvedeniya Ceftriaksona. Tendencii razvitiya sovremennoj mediciny: mat. Intern. vysshem urovne.. nauch.- prakt. Konf. [Status of the lymphatic drainage of the hind limb of rats under different regimens of administration of Ceftriaxone. Trends in the development of modern medicine: Mat. Intern. the highest level.. scientific.- pract. Conf.] (06. August, 2012). M., 2012; 59 -63.
  6. In Savelyev.With. Hirurgicheskie infekcii kozhi i myagkih tkanej: rossijskie nacional'nye rekomendacii (ROH, rishi, MEZHDUNARO, Mekka, AFR). [Surgical infections of skin and soft tissue: Russian National Recommendations (ROCH, RISHI, ACHM, Makkah, AFR).] M., 2009.
  7. Shalimov S. A., Radzikhovsky A. P., Keisevich L. V. Rukovodstvo po ehksperimental'noj hirurgii. [Guide experimental surgery.] M.: Medicine, 1989,; 272.
  8. Red book: 2006 report of the Committee on infectious diseases, 27th edition. The American Academy of Pediatrics, Larry K. Pickering (editor). [2006 report of the Committee on infectious diseases, 27th edition.] The American Academy of Pediatrics, Larry K. Pickering (editor). 2006; 992.
  9. Gorimch S. L., J. G. Baraett, Blachlow R. N. Infekcionnye Bolezni. [Infectious Diseases.] W. B. Saunders Company. 1998; 1025-1037.
  10. Sweet, R. L., D. Grady, K. Kerlikowske, D. A. Grimes In Many Respects It Provides. and Gynec. 1996; 87: 5: 2: 884-890.
  11. Taylor E. W. Antibiotikov; i himioterapii. CHerchill' Livingstoun [Antibiotical and chemotherapy. Churchill Livingstone.] 1997; 594-614.


Abstract - 81

PDF (Russian) - 50



Copyright (c) 2014 .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies