Change of some coagulation-lytic system of blood in the ischemic area of the small intestine after intravenous, subcutaneous and intraoperative paravasal routes of administration of heparin in the experiment

The aim of the study was a comparative evaluation of the effectiveness of distinct prevention of abdominal adhesions after
intravenous, subcutaneous and intraoperative paravasal routes of administration of heparin in conditions of ischemic injury
of the small intestine. The paper presents an experimental study conducted on 40 adult mongrel dogs were divided into 4
groups (10 dogs in each group). The first group formed the stomach in kind, which was not carried out heparin, the second
- the animals, which the eye was performed, intravenous heparin, and the third - the animals, which produced subcutaneous
heparin and the fourth - of animals, which was carried out intraoperative heparin in the tissue of a neurovascular beam
mesentery. From the venous vessel, directly adjacent to the ischemic area of the small intestine 20 minutes after creating
the model for the fracture circulatory organs are made to draw blood with subsequent study of several coagulation-analytic
system of blood: clotting time by Lee-White, prothrombin time and prothrombin ratio, the activity of antithrombin III.
After taking the blood from the venous vessel last tied. Then, the surgical wound sutured in layers. Postoperatively, any
treatment of animals was conducted. At various times after surgery were evaluated functional and morphological changes in
the experimental section of the intestine. Based on the data shown conclusive advantages of intraoperative paravasal the set
route of administration of heparin in the prevention of abdominal adhesions.