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Perforation of the Sigmoid Colon in Vasculitis in COVID-19 Patients
- Authors: Tarasenko S.V.1,2, Glotov D.A.1,2, Zhuchkova U.V.2
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Affiliations:
- Ryazan State Medical University named after Academician I.P. Pavlov
- City Clinical Hospital of Emergency Medical Care
- Issue: Vol 17, No 4 (2024)
- Pages: 204-208
- Section: Cases from practice
- URL: https://vestnik-surgery.com/journal/article/view/1805
- DOI: https://doi.org/10.18499/2070-478X-2024-17-4-204-208
- ID: 1805
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Abstract
The aim of the study was to investigate the main manifestations and pathological changes in the tissues under the sigmoid colon perforation in patients with COVID-19.
Materials. The study involved analysis of medical histories of 40 patients with sigmoid colon perforation associated with COVID-19. All patients showed similar symptoms (increasing respiratory failure, dyspnea, high body temperature), followed by the development of the sigmoid colon perforation due to the violation of intravascular hemostasis. In 25% of patients, perforation developed already on the second or third day from the onset of ARVI symptoms, in 75% - on the fifth or sixth day from the onset of the disease.
Results. The analysed case histories and the results of histological examination of biopsy or pathological material demonstrated similarities in the clinical presentation of the disease and morphological changes in the affected area of the sigmoid colon. The main symptoms and syndromes are presented using the example of a clinical case.
Conclusion. The patient developed complications at the final stage of COVID-19 disease and this was associated with inflammation of the mesentery arteriole walls and the formation of occlusive blood clots in their lumen, which led to the development of the sigmoid colon perforation.
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About the authors
Sergey V. Tarasenko
Ryazan State Medical University named after Academician I.P. Pavlov; City Clinical Hospital of Emergency Medical Care
Author for correspondence.
Email: surgeonsergey@hotmail.com
ORCID iD: 0000-0002-1948-5453
SPIN-code: 7926-0049
M.D., Professor, Head of the Department of Hospital Surgery, Honored Doctor of the Russian Federation, surgeon of the highest category, chief physician of the emergency hospital, surgeon of the Department of Acute surgical diseases of the liver and pancreas of the emergency hospital
Russian Federation, Ryazan; RyazanDmitry A. Glotov
Ryazan State Medical University named after Academician I.P. Pavlov; City Clinical Hospital of Emergency Medical Care
Email: ddaleksandrovich29@mail.ru
ORCID iD: 0000-0002-7419-3728
SPIN-code: 5463-8032
assistant of the Department of Hospital Surgery, Ryazan State Medical University named after Academician I.P. Pavlov, a surgeon of the Department of Acute Surgical Diseases of the Liver and pancreas
Russian Federation, Ryazan; RyazanUlyana V. Zhuchkova
City Clinical Hospital of Emergency Medical Care
Email: juchkova.uliana@gmail.com
ORCID iD: 0000-0001-9286-1833
surgeon of the first category, a surgeon at the Department of minimally invasive surgery
Russian Federation, RyazanReferences
- Vremennye metodicheskie rekomendatsii profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID-19) Ministerstvo zdravookhraneniya Rossiiskoi Federatsii. (in Russ.)
- Maksimov VA, Torshin IYu, Chuchalin AG. Efficacy and safety of the polypeptide drug (laennec) in COVID-19 therapy. Eksperimental'naya i klinicheskaya gastroenterologiya. 2020; 6: 55-63. (in Russ.)
- Khlynova OV, Karpunina NV, Vasilets LM. COVID-19 and damage to internal organs: what do we know when we reach the plateau? Eksperimental'naya i klinicheskaya gastroenterologiya. 2020; 8: 4-9. (in Russ.)
- Mayev IV, Shpektor AV, Vasilyeva EY. New coronavirus infection COVID-19: extrapulmonary manifestations. Terapevticheskii arkhiv. 2020; 8:4-11. (in Russ.)
- Abdurakhimov AH, Hegai LN, Yusupova SK. COVID-19 and its complications. Re-health journal. 2021; 4; 61-74. (in Russ.)
- Zagiullin NSh, Gareeva DF, Ishmetov VSh, Pavlov AV, Plotnikova MR. Renin-angiotensin system in the new coronavirus infection COVID-19. Arterial hypertension. 2020; 26(3): 240-247. (in Russ.)
- Fisun AYa, Cherkashin DV, Tyrenko VV, Zhdanov KV, Kozlov KV. The role of the renin-angiotensin-aldosterone system in interaction with the SARS-CoV-2 coronavirus in the development of strategies for the prevention and treatment of new coronavirus infection (COVID-19). Arterial hypertension. 2020; 26(3): 248-262. (in Russ.)
- Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, Winter H, Meister M, Veith C, Boots AW, Hennig BP, Kreuter M, Conrad C, Eils R. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J. 2020;39(10):e105114. doi: 10.15252/embj.20105114.
- Kulagina MG, Yushchuk ND, Vengerov YY. Koronavirusnaya infektsiya. Infektsionnye bolezni: natsional'noe rukovodstvo. M.: GEOTAR-Media. 2018; 759-768. (in Russ.)
- Kuba K, Imai Y, Rao S, Gao H, Guan BF. Сrucial role of angiotensin converting enzyme 2(ACE2) in SARS coronavirus – induced lung injury. Nat Med. 2019;11(8):875-879.
- Mao R, Qiu Y, He JS, Tan JY, Li XH, Liang J, Shen J, Zhu LR, Chen Y, Iacucci M, Ng SC, Ghosh S, Chen MH. Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020;5(7):667-678. doi: 10.1016/S2468-1253(20)30126-6.
- Drapkina OM, Vasilyeva LE. Controversial issues of the use of angiotensin converting enzyme inhibitors and angiotensin receptor antagonists in patients with COVID-19. Kardiovaskulyarnaya terapiya i profilaktika. 2020; 19(3): 319-326. (in Russ.)
- Gorenkov DV, Khantimirova LM, Shevtsov VA, Rukavishnikov AV, Merkulov VA, Olefir YuV. Outbreak of a new infectious disease COVID-19:b-coronaviruses as a threat to global health. BIOpreparaty. Profilaktika, diagnostika, lechenie. 2020; 20(1): 6-20. (in Russ.)
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