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Effect on mexicor syndrome during abdominal hypertension in experimental total peritonitis
- Authors: 1, 1, 1, 1, 1, 1
-
Affiliations:
- Kursk state medical University
- Issue: Vol 3, No 3 (2010)
- Pages: 222-226
- Section: Original articles
- URL: https://vestnik-surgery.com/journal/article/view/543
- DOI: https://doi.org/10.18499/2070-478X-2010-3-3-222-226
- ID: 543
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Abstract
A Mexicor’s effect onto microcirculation disorders, endothelial dysfunction, and free radical lipid oxidation has been assessed in 166 male Vistar rates having experimental total peritonitis complicated by intraabdominal hypertension. All animals have been selected into three groups: intact, control, and basic respectively. An intraabdominal injection of 10% concentration of fecal mixture was used to cause peritonitis. Thereby intraabdominal hypertension was created by double fold plasty of the abdominal wall aponewrosis. A 10mg/kg Mexicor injections during 7 days were used in the basic group rates. During the treatment it was noticed that Mexicor injection increased microcirculation characteristics in the colon wall by 45,5%. It also lead to drop of free radical lipid oxidation characteristics by 1,8 times, NO concentration in 1,6 times, and intraabdominal
pressure in 1,4 times comparing to the control group.
About the authors
Kursk state medical University
Author for correspondence.
Email: author@vestnik-surgery.com
doctor of medical Sciences, Professor, head of chair of General surgery Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
doctor of biological Sciences, Director of scientific research Institute of ecological medicine of the Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
the doctor-Intern of surgical branch of city clinical hospital of ambulance of the city of Kursk Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
the candidate of medical Sciences, associate Professor, Department of anesthesiology, reanimatology and intensive therapy of postgraduate faculty of the Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
PhD, associate Professor of the chair of General surgery Kursk state medical University Russian Federation
Kursk state medical University
Email: author@vestnik-surgery.com
PhD, associate Professor in the Department of operative surgery and topographic anatomy of Kursk state medical University Russian Federation
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