Infl uence of the genetic factors on the risk of the disease and characteristics of the course of the acute alcohol pancreatitis


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Abstract

The analysis was made about distribution of polymorphous variants of the gene of the cation tripsinogen (PRSS1) and genes of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1). This research was held according to the group of people, who have the disease of alcohol pancreatitis (49 people). This group of people was compared with donors (69 people). The gene mutation which exists under the condition of alcohol aggression was the reason of appearing the acute pancreatitis. In Krasnoyarsk 51% of people have the gene of alcohol aggression, which causes the existence of the acute pancreatitis. Destructive pancreatitis was made after an patient’s alcohol ingestion. This comprised 50% and 41,6 % of ill people, who have a “neutral” genotype. When there is a mutation of genes GSTM1 And GSTT1, overall affection of the pancreatic gland begins. If patients have a “neutral” genotype GSTM1, GSTT1 and have the acute alcohol pancreatitis, the alteration of cellicolous metabolic process begins.

About the authors

Красноярский государственный медицинский университет им. профессора В.Ф.Войно-Ясенецкого

Author for correspondence.
Email: admin@vestnik-surgery.com
доктор медицинских наук, профессор, заслуженный деятель науки Российской Федерации, заведующий кафедрой общей хирургии Красноярского государственного медицинского университета им. профессора В.Ф.Войно-Ясенецкогo

Красноярский государственный медицинский университет им. профессора В.Ф.Войно-Ясенецкого

Email: olga-pervova@mail.ru
доктормедицинских наук, профессор кафедры общей хирургии Красноярского государственного медицинского университета им. профессора В.Ф.Войно-Ясенецкого

Красноярский государственный медицинский университет им. профессора В.Ф.Войно-Ясенецкого

Email: admin@vestnik-surgery.com
доктор медицинских наук, профессор, заведующий кафедрой хирургических болезней №1 с курсом сердечно-сосудистой хирургии им. профессора А.М.Дыхно Красноярского государственного медицинского университета им. профессора В.Ф.Войно-Ясенецкого

Сибирский Федеральный университет

Email: admin@vestnik-surgery.com
кандидат биологических наук, доцент кафедры биохимии и физиологии животных тканей Сибирского Федерального университета

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