Correction of lipid-transport system at experimental widespread purulent peritonitis


Cite item

Full Text

Abstract

Research is spent on 40 rabbits-males of chinchilla breed. For the first time influence of a preparation of omega-3 fatty acids «Omegaven» on protein-lipid spectrum of blood is studied at an experimental widespread purulent peritonitis. It is established that in the postoperative period «Omegaven» effectively influences on protein-lipid spectrum of blood by prevention of sharp decrease in quantity of proteins, lipoproteins of high density (HDL) and maintenance of triglyceride’s growth. Positive action of the preparation also is connected with percentage decrease of lisophosphatides and level increase of polyglycerophosphatides in phopholipid spectrum of HDL.

About the authors

Первый Московский государственный медицинский университет им. И.М.Сеченова

Author for correspondence.
Email: author@vestnik-surgery.com
д.м.н., проф., академик РАМН, Президент Ассоциации общих хирургов Российской Федерации, зав. кафедрой общей хирургии Первого Московского государственного медицинского университета им. И.М.Сеченова, председатель проблемной комиссии «Инфекция в хирургии» Межведомственного научного Совета по хирургии РАМН и Министерства здравоохранения Российской Федерации.

Первый Московский государственный медицинский университет им. И.М.Сеченова

Email: author@vestnik-surgery.com
к.м.н.,  док-торант кафедры общей хирургии Первого Москов-ского государственного медицинского университе-та им. и.М.сеченова; e-mail: vkosinets@yandex.by

References

  1. Gostishchev V.K., Sazhin V.P., Avdovenko A.L. Peritonit GEOTAR-Media M 2002; 238.
  2. Eriukhin I.A., Shliapnikov S.A., Efimova I.S. Peritonit i abdominal'nyi sepsis [Peritonitis and abdominal sepsis]. Inf. v khir. 2004; 2: 2-7.
  3. Efimenko, N.A. Rozanov V.E., Bolotnikov A.I. Immunopatogenez i kontseptsiia sovremennoi immunoterapii peritonita u postradavshikh s tiazheloi sochetannoi travmoi zhivota [Immunopatogenez and the concept of modern immunotherapy peritonitis in patients with severe concomitant injury of the abdomen] OOO «AVTOGRAF M 2008; 302.
  4. Keits M. Tekhnika lipidologii [Equipment lipidology]. Mir M 1975; 76, 138-140, 310-311.
  5. Osochuk S.S. Izmeneniia lipidtransportnoi sistemy pri eksperimental'nom peritonite u krys[Changes lipidtransport system in experimental peritonitis in rats]. Biulleten' eksperimental'noi biologii i meditsiny.2002; 8: 169-171.
  6. Pokrovskii A.A. Biokhimicheskie metody issledovaniia [Biochemical methods of investigation] Meditsina. M 1969; 477.
  7. Savel'ev B.C., Gel'fanda B.R., Filimonova M.I. Peritonit: praktich. rukov. [Peritonitis: A Practical Guide] Litterra M 2006; 208.
  8. Khanevich, M.D., Selivanov E.A., Starokon' P.M. Peritonit: Infuzionno-transfuzionnaia i detoksikatsionnaia terapiia [Peritonitis: infusion-transfusion therapy and detox] MedEkspertPress M 2004; 205.
  9. Zingerenko V.B. Effektivnost' gliutamina v korrektsii metabolicheskikh narushenii u bol'nykh peritonitom [The effectiveness of glutamine in the correction of metabolic disorders in patients with peritonitis]. Inf. v khir. M 2008; 1: 45-50.
  10. Iupatov, G.I. Immunnaia i lipidtransportnaia sistemy: kliniko metabolicheskie aspekty [The immune and lipid transport system: clinical and metabolic aspects]: avtoref. dis. ... d-ra med. nauk Vitebsk 2003; 41.
  11. Laurila A. et al.
  12. Associacija helikobakternoj infekcii s povyshennym urovnem lipidov v syvorotke krovi. Ateroskleroz [Association of Helicobacter pylori infection with elevated serum lipids. Atherosclerosis]. 1999; 142: 207–210.
  13. Auerbach, B.J., Parks J.S Lipoproteinov otklonenija, svjazannye s lipopolisaharida inducirovannoj lecitina: holesterin aciltransferazy i deficit lipazy [Lipoprotein abnormalities associated with lipopolysaccharide-induced lecithin: cholesterol acyltransferase and lipase deficiency] J. Biol. Chem. 1989;. 264: 10264-10270.
  14. Byrne, C.D. Bogatykh triglitseridami lipoproteinov: sviaz' s aterosklerozom oposredovannaia provospalitel'nykh i prokoaguliantnoi fenotipa? [Triglyceride-rich lipoproteins: are links with atherosclerosis mediated by a procoagulant and proinflammatory phenotype?] Atherosclerosis. 1999; 145: 1-15.
  15. Festa A. et al.
  16. Khronicheskoe subklinicheskoe vospalenie kak chast' sindroma rezistentnosti k insulinu [Chronic subclinical inflammation as a part of the insulin resistance sindrome]. The Insulin Resistance Atherosclerosis Study (IRAS) Circulation. 2000; 102; 42-47.
  17. Harris H.W. et al. Chylomicrons izmenit' sud'bu endotoksina, umen'shaia vysvobozhdenie faktora nekroza opukholi i predotvrashcheniia smerti J. Clin [Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death J. Clin]. Invest. 1993; 91: 1028-1034.
  18. Clarissa M., Whitehead Alexander Uhlar. Syvorotochnyi amiloid A, glavnym pozvonochnoe ostroi fazy reagentov [Serum amyloid A, the major vertebrate acute-phase reac-tant] Eur. J. Biochem. 1999; 265: 501-523.
  19. D. Sander et al.
  20. Rasshirennyi progressirovanie rannego ateroskleroza sonnykh arterii sviazano s khlamidiinoi pnevmonii (Taivan' ostryi respiratornyi) seropozitivnost'iu [Edvanced progression of early carotid atherosclerosis is related to Chlamidia pneumoniae (Taiwan acute respiratory) seropositivity] Circulation. 2001; 103: 1390–1395.
  21. Gallin, J.I., Kaye D., O'Leary W.M Syvorotochnye lipidy infektsii [Serum lipids in infection]. N. Engl. J. Med. 1969; 281: 1081–1086.
  22. Woods A. et al. Genetika vospaleniia i riskom razvitiia ishemicheskoi bolezni serdtsa: tsentral'naia rol' interleikina-6 [Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6]Europ. Heart. J. 2000; 21: 1574-1583.
  23. Gornall, A.C., Bardawill C.J., David M.M
  24. Opredelenie syvorotochnykh belkov s pomoshch'iu reaktsii biureta [Determination of serum proteins by means of the biuret reaction] J. Biol. Chem. 1949;. 177: 751-766.
  25. Chiarla C. et al. Giperkholesterinemiia v kriticheskoi bolezni [Hypocholesterolemia in critical illness] Critical Care Medicine. 2009; 37: 2681-2682.
  26. Bonnefoy M et al Giperkholesterinemii u gospitalizirovannykh pozhilykh: otnosheniia s vospalitel'nym i pitatel'nogo statusa [Hypocholesterolemia in hospitalized elderly: relations with inflammatory and nutritional status] Rev. Med. Interne. 2002; 23: 991-998.
  27. Khovidhunkit Weerapan et al. Infektsiei i vospalenie Indutsirovannye proaterogennymi Izmeneniiami lipoproteinov
  28. [Infection and InflammationInduced Proatherogenic Changes of Lipoproteins] The Journal of Infectious Diseases. 2000; 181: 462-472.
  29. Kruger, P.S.
  30. Zabud'te gliukozu: chto o lipidakh v kriticheskoi bolezni? [Forget glucose: what about lipids in critical illness?] Crit. Care Resusc. 2009; 11: 305-309.
  31. Hardardóttir I. et al LPS i tsitokiny reguliruiut dopolnitel'nye pechenochnye urovni mRNK apolipoproteinov vo vremia otvetnoi reaktsii ostroi fazy v siriiskikh khomiakov [LPS and cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamsters] Biochim. Biophys. Acta. 1997; 1344: 210-220.
  32. Mayer K. et al. Parenteral'noe pitanie s ryb'im zhirom modulirovat' tsitokinovogo otveta u patsientov s sepsisom [Parenteral nutrition with fish oil modulate cytokine response in patients with sepsis] Am. R. Respir. Crit. Care. Med. 2003; 167; 1321-1328.
  33. Salazar, A., Pinto X, Mana J.
  34. Syvorotochnye markery vospaleniia pri sarkoidoze i drugie sistemnye rasstroistva: syvorotochnyi amiloid A i kholesterina lipoproteinov vysokoi plotnosti [Serum amyloid A and highdensity lipoprotein cholesterol: serum markers of inflammation in sarcoidosis and other systemic disorders] Eur. J. Clin. Invest. 2001; 31: 1070-1077.
  35. Bonville D.A. et al. Otnosheniia giperkholesterinemii k kontsentratsii tsitokinov i smertnosti bol'nykh v kriticheskom sostoianii s sindromom sistemnoi vospalitel'noi reaktsii [The relationships of hypocholesterolemia to cytokine concentrations and mortality in critically ill patients with systemic inflammatory response syndrome] Surg. Infect. (Larchmt). 2004; 5: 39-49.
  36. Valentine, R.C., Valentine D.L
  37. Omega-3 zhirnye kisloty v kletochnykh membranakh: odno poniatie [Omega-3 fatty acids in cellular membranes: a unified concept] Prog. Lipid. Res. 2004; 43: 383-402.
  38. Vaskovsky, V.E., Kostetsky E.J.,. Vassenolin J.M A universal reagent for phospholipid analysis J. Chromatogr. 1975;. 114: 129-141.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies