Liver Function in the Syndrome of Multiorgan Failure in Patients with Acute Small Intestine Obstruction


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Abstract

The main problems of modern surgery are in the field of emergency abdominal pathology. Relevant issues are the treatment of patients with acute surgical abdominal disease, including acute small intestine obstruction, complicated by peritonitis and acute liver failure. Deaths in acute small intestine obstruction is 10,7-64,7%, while the complication of peritonitis mortality reaches 47- 100%. Mortality in patients with peritonitis, complicated by acute liver failure reaches 73% with no tendency to decrease even in the core of modern hospitals. In peritonitis disturbed barrier function of the liver with «breakthrough» of infectious and toxic agents into the systemic circulation and the development of multiple organ dysfunction syndrome and toxic-septic shock. It is obvious that without a deep knowledge of the morphofunctional changes in the body of endotoxemia and after its removal, there can not be a qualitative improvement in the pathogenetic therapy of patients with acute liver failure complicating during peritonitis. We need experimental-morphological study - an experimental model of acute small intestine obstruction are needed, which would investigate morfofuntsionalnye conversion in the liver in the dynamics of the disease, to determine the staging of these changes and, consequently, on the basis of the data to justify the preventive and therapeutic tactics in the preoperative and early postoperative period

About the authors

Москва, Российская Федерация
Государственный институт усовершенствования врачей Министерства обороны Российской Федерации

Author for correspondence.
Email: author@vestnik-surgery.com

Москва, Российская Федерация
Государственный институт усовершенствования врачей Министерства обороны Российской Федерации

Email: author@vestnik-surgery.com

Первый Московский государственный медицинский университет им. И.М. Сеченова

Email: author@vestnik-surgery.com

Москва, Российская Федерация
Государственный институт усовершенствования врачей Министерства обороны Российской Федерации

Email: author@vestnik-surgery.com

Первый Московский государственный медицинский университет им. И.М. Сеченова

Email: author@vestnik-surgery.com

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