Experimental Study of Local Cryohemostasis in Cases of Liver and Spleen Damage


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Abstract

Relevance One of the features of traumatic epidemic peace time is an increase in the frequency of injuries of the organs of the abdominal cavity. Abdominal trauma occupy one of the per-out places in the structure of injuries of various systems of the body, and their frequency is 12-40,5%. In Western European countries in peace-time the specific weight of abdominal injury reaches 1.5-4.4% of all injuries. In different regions of our country the abdominal trauma falls from 1.5 to 36.5% from the number of injuries peace time, but their frequency and severity, in spite of the tendency to decrease, remain high. Injuries of parenchymatous organs are one of the most severe types of surgical pathology, both in peacetime and in wartime. The condition of the injured is determined by the multiplicity damage of parenchymatous organs, as well as the volume and intensity of blood loss. One of actual problems of surgery at the present time is to stop the bleeding in the event of damage of the liver, spleen. The purpose of the study To explore, experiment and make a comparative assessment of cryotherapy and some local applicator means of hemostasis in wounds of the liver and spleen. Materials and methods The paper presents experimental data showing changes in the tissue of liver and spleen under low temperature (-195,75°С) when modeling the wounds of various depth and length of the given organs. Simultaneously, in the control group the use of some of the adhesive hemostatic agents in cases of liver and spleen injury on a equatable number of experimental animals was evaluated. In all of the cases a histological study of areas of cryoapplication and adhesion of local hemostasiс agents was conducted. Results and their discussion It was proven that it takes significantly less time for hemostasis with the help of cryoapplication in comparison with hemostatic sponges. In addition to that, cryogenic method has antiadhesive activity and to a lesser extent causes inflammatory changes in the tissues as well as it allows for the formation of connective tissue in the place of the stoppage of bleeding significantly faster. Conclusions Local cryohemostasis can be used in cases of parenchymatous hemorrhage for an ultimate or temporary hemostasis. Proven lesser degree of severity of inflammatory changes when using cryohemostasis and showed a significant decrease in inflammatory reaction after cryohemostasis in the early stages of the experiment, which is not observed when using hemostatic sponge.

About the authors

Volgograd State Medical University, Volgograd, Russian Federation

Author for correspondence.
Email: author@vestnik-surgery.com
post-graduate student of the chair of hospital surgery of the Volgograd State Medical University.

Volgograd State Medical University, Volgograd, Russian Federation

Email: maskins@bk.ru
head of the chair of hospital surgery of the Volgograd State Medical University, doctor of medicine

Volgograd State Medical University, Volgograd, Russian Federation

Email: author@vestnik-surgery.com
assistant of the chair of hospital surgery of the Volgograd State Medical University, candidate of medical Sciences.

Volgograd State Medical University, Volgograd, Russian Federation

Email: author@vestnik-surgery.com
assistant of the chair of hospital surgery of the Volgograd State Medical University, candidate of medical Sciences

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