Changes of the Immune Status at Suffered from Burns, Including at Mass Accidents


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Abstract

Relevance Burn injury is one of the most severe types of traumatism. In this regard, infectious complications of burn disease are significantly more likely to develop, even in patients with relatively small area burns, and mortality rate increases substantially.

The purpose of the study To detect changes in the amount of functional activity and to determine the prognostic significance of immune cells.

Materials and methods The study was conducted on 38 patients at different periods of burn disease, depending on the area of   the burn injury and its depth, in the Burn Center of the Institute of Surgery named after A.V. Vishnevsky and the City Burn Center at the 36th City Clinical Hospital. Phenotypic analysis of lymphocytes, granulocytes and monocytes (constitutive and activation markers, the functional activity of cells) was performed.

Results and their discussion In the period of acute burn toxemia in patients, significant changes in many immune parameters remain and are quite serious in 10-14 days after burn injury. In this regard, two cocurrent alternative processes are generally develop - hyperactivation of the immune system (leukocytosis with a shift of the blood count to the left, a sharp increase of granulocytes expressing the receptor of LPS and a high affinity Fcγ-receptor, increase of their oxygen metabolism, the functional activation of HLA-DR + monocytes) and its deep deficit (natural killer cells, lymphocytes, cytotoxic CD8 + T-cells, T-helpers and overall T-lymphocytes, B-lymphocytes).

Conclusion Based on the analysis of the complex immune parameters, it is possible not only to predict the course and outcome of burn disease, but also to determine the necessary treatment in patients with severe burns, immunotherapy and evaluate its effectiveness.

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About the authors

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Author for correspondence.
Email: vishnevskogo@ixv.ru
Doctor of Medicine, Prof., honored Scientist of Russia, Recipient of the Prize of M.P Chumakov, head of the Group of Clinical Immunology, Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Doctor of Medicine, Prof., Laureate of the State Prize of the Russian Federation, the Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Doctor of Medicine, Staff Member of the Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Doctor of Medicine, Staff Member of the Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Candidate of Medicine, Senior Researcher of the Group of Clinical Immunology, Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Candidate of Medicine, Senior Researcher of the Group of Clinical Immunology, Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Candidate of Medicine, Senior Researcher of the Group of Clinical Immunology, Institute of Surgery named after A.V. Vishnevsky

Institute of Surgery Vishnevsky, Moscow, Russian Federation

Email: author@vestnik-surgery.com
Intramural Postgraduate Student of the Institute of Surgery named after A.V. Vishnevsky

References

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