The first experience of application infliximab at patients about a steroid-refractory and a steroid-dependent forms of a nonspecific ulcerative colitis


Cite item

Full Text

Abstract

It is well known that corticosteroids are the current first-line therapy for patients with moderate or severe form ulcerative colitis (UC). About 30-35% of patients do not respond to corticosteroids and require alternative anti-inflammatory agent. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a central role in mucosal inflammation. Infliximab, a monoclonal antibody against TNF-alpha has been proved highly effective in the treatment of steroid–dependent and steroid–resistant forms of UC.

About the authors

Белгородская областная клиническая больница Святителя Иоасафа, Белгородский государственный университет

Author for correspondence.
Email: okb@bel.ru
доктор медицинских наук, профессор, заведующий кафедрой клинических дисциплин ИПМО Белгородского государственного университета, главный врач Белго- родской областной клинической больницы Святителя Иоасафа.

Белгородская областная клиническая больница Святителя Иоасафа, Белгородский государственный университет

Email: okb@bel.ru
доктор медицинских наук, профессор кафедры клинических дисциплин ИПМО Белгородского государственного университета.

Белгородская областная клиническая больница Святителя Иоасафа, Белгородский государственный университет

Email: ellochka1981@yandex.ru
врач-хирург отделения гравитационной хирургии Белгородской областной клинической больницы Святителя Иоасафа.

References

  1. Belousova E.A. Terapiia vospalitel'nykh zabolevanii
  2. kishechnika: nastoiashchee i budushchee.[Therapy of inflammatory diseases bowel: Present and Future.] Vrach 2002; 2: 36-39.
  3. Belousova E.A. Immunnye mekhanizmy pri vospalitel'nykh zabolevaniiakh kishechnika i printsipy selektivnoi immunokorrektsii.[Immune mechanisms in inflammatory bowel disease and immune selective principles.] Ros. zhurn. gastroenterologii, gepatologii, koloproktologii 1999; 9: 4: 48-57.
  4. Belousova E.A., Morozova N.A., Nikitina N.V. Infliksimab (remikeid) v lechenii refrakternykh form bolezni Krona. [Infliximab (Remicade) in the treatment of refractory forms of Crohn's disease.] RMZh 2005; 7: 1: 28-32.
  5. Grigor'eva G.A., Meshalkina N.Iu. Bolezn' Krona.[Crohn's disease.] M.:
  6. OAO «Izdatel'stvo «Meditsina» 2007; 184.
  7. Komarov F.I., Osadchuk A.M., Osadchuk M.A., Kvetnoi
  8. I.M. Nespetsificheskii iazvennyi kolit. [Nonspecific ulcerative colitis] M.: OOO «Meditsinskoe informatsionnoe agentstvo» 2008; 256.
  9. Lopatkina T.N., Moiseev S.V. Ingibitory faktora
  10. nekroza opukholi al'fa v lechenii vospalitel'nykh za-
  11. bolevanii kishechnika.[Inhibitors of tumor necrosis factor-alpha in the treatment of inflammatory bowel disease.] Klinicheskaia farmakologiia i
  12. terapiia 2007; 2-7.
  13. Rumiantsev V.G., Rogozina V.A., Tsaregorodtseva T.M. Infliksimab: novaia era v terapii vospalitel'nykh zabolevanii kishechnika.[Infliximab: a new era in the treatment of inflammatory bowel disease.] Gastroenterologiia 2004; 1: 25-6.
  14. Khalif I.L., Loranskaia I.D. Vospalitel'nye zabolevaniia kishechnika (nespetsificheskii iazvennyi kolit i bolezn' Krona): klinika, diagnostika i lechenie.[Inflammatory bowel disease (ulcerative colitis
  15. and Crohn's disease): clinical features, diagnosis and treatment.] M.:
  16. «Miklosh» 2004; 88.
  17. Shifrin O.S. Remikeid – novyi etap v lechenii vospa-
  18. litel'nykh zabolevanii kishechnika.[Remicade - a new stage in the treatment of inflammatory bowel diseases.] Consilium medicum
  19. ; prilozhenie «Gastroenterologiia» 1: 13-15.
  20. Chey W.Y., Hussain A., Ryan C. et al. Infliksimab dlia
  21. tugoplavkii nespetsificheskogo iazvennogo kolita. [Infliximab for
  22. refractory ulcerative colitis.[ Am J Gastroenterol 2001; 96:
  23. -66.
  24. Feagan B.G. Infliksimab v lechenii bolezni Krona. [Infliximab in the treatment of Crohn’s disease.] Scand J Gastroenterol 2000;14 (Suppl. C). 6B.
  25. Kirsner J.B.Vospalitel'noe zabolevanie kishechnika. [Inflammatory bowel disease] 2000; 800.
  26. Jarnerot G., Hertervig E., Friis-Liby I. et al.
  27. Infliksimab, kak spasitel'naya terapiia pri tiazheloi forme do umerennoi ostryi iazvennyi Kolit: a randomizirovannoe, platsebo-kontroliruemoe issledovanie. [Infliximab as Rescue Therapy in Severe to Moderate Severe Ulcerative Colitis: a Randomised, Placebo-controlled Study.]
  28. Gastroenterology 2005; 128: 1805-11.
  29. Lemann M., Mary J.Y., Duclos B. et al. Infliksimab plius azatioprin dlia patsientov s bolezn'iu steroidozavisimoi Krona: randomizirovannoe platsebo-kontroliruemoe issledovanie.[Infliximab plus azathioprine for steroid-dependent Crohn’s disease patients: a randomized placebo-controlled trial.] Gastroenterology
  30. ; 130: 4: 1054-61.
  31. Rutgeerts P., Feagan B., Olson A. et al. Randomizirovannoe Platsebo-kontroliruemoe issledovanie infliksimaba terapii dlia Aktivnyi Iazvennyi kolit: AST-1 Trial. [A Randomized
  32. Placebo-Controlled Trial of Infliximab Therapy for Active
  33. Ulcerative Colitis: AST-1 Trial.] Gastroenterology 2005;
  34. (Suppl. 2).
  35. Rutgeerts P., Sanborn W., Feagan B. et al. Infliksimab dlia induktsii i podderzhivaiushchei terapii iazvennogo kolita. [Infliximab for
  36. Induction and Maintenanse Therapy for Ulcerative Colitis.]
  37. N Eng J Med 2005; 353: 2462-76.
  38. Sandborn W., Rachmilewitz D., Hanauer S. et al. Infliksimab Induktsionnye i Maintenanse terapiia iazvennogo kolita: AST-2 Trial. [Infliximab Induction and Maintenanse Therapy for Ulcerative Colitis:
  39. the AST-2 Trial.] Gastroenterology 2005; 128(Suppl. 2).
  40. Sandborn W.J., Targan S.R.Biologicheskaia terapiia vospalitel'nykh
  41. zabolevaniy kishechnika. [Biologic therapy of inflammatory
  42. bowel disease.] Gastroenterology 2002; 122: 6: 1592-607.
  43. Sands B.E., Tremaine W.J., Sanborn W.J. et al.[Infliksimab v lechenii tiazheloi steroid-tugoplavkogo iazvennyi kolita: pilot stu-du.[Infliximab in the treatment of severe steroid-refractory ulcerative colitis:a pilot stu-dy.] IBD 2001; 7: 83-88.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 ., ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies